WIPEOUT™ COMBATS DOWN-REGULATION OF METABOLIC FACTORS Getting really lean is a tough proposition for almost everyone. Even if you're in the gym daily and eat perfectly, results are often slow. Today's newest research studies reveal the reason. They show that your body begins to down-regulate fat burning after just one workout!1 Down-regulation is defined as the process of reducing or suppressing a response to a stimulus. In the case of dieting, you eat fewer calories and your body responds by slowing down your metabolism. Which might explain why everyone is dieting and training yet few of us ever reach that ultimate rock-hard leanness. So, if our own bodies are working against us by burning less fat, how can any of us achieve our body-weight or fat-percentage goals? You really can't blame your body. It was designed to keep you from starving. The minute you start losing weight your body does everything possible to conserve calories, and practically compels you to consume more calories! Anyone who has tried to lose weight knows how easily the pounds come-off during the first week of dieting, and how progressively hard it becomes as you get closer to your goal. The single biggest reason that an athlete finds it so hard to get really lean while retaining their muscle mass is metabolic down-regulation! There are four general metabolic stages of fat loss and metabolic down-regulation occurs in all of them. After an extensive review of the most current scientific literature, Champion Nutrition's product development team has introduced a product that addresses the real obstacle to consistent fat loss: down-regulation. The product is called WipeOut™ Fat Burner. The following article for this exciting new thermogenic product explains how WipeOut™ Fat Burner earns the position as the first thermogenic fat-loss product designed from the ground up to address each of The Four Stages of Fat Loss. Results in Fat Burning Driven by Science Most generic fat burners contain harsh stimulants that make your heart race and your hands shake. WipeOut™ is different. It is clinically designed for the unique challenges faced by serious athletes seeking to retain maximum muscle mass while attaining ultimate leanness. Here is a brief summary of the additional technology contained in WipeOut™. Liver Energy A principle organ of down-regulation in the body, as far as an athlete is concerned, is the liver. In fact, the liver is responsible for over 60 functions in the process of your body's ability to recovery. To prevent down-regulation and continue normal function the liver needs energy. Researchers have found that a specialized ingredient that has been added to WipeOut™, 7-Keto DHEA (another name for 7-Oxo DHEA) induces the thermogenic enzymes in liver mitochondria, sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzymes.¹⁰ The genius of 7-Keto DHEA is that it helps the liver generate the energy it needs from fat!¹¹ The result is that the liver makes more ATP to boost its functions in recovery. Because the liver stays in a higher energetic state, it signals the rest of the body that all is well. Down-regulation stops before it can even start. Reduces Fat Storage The flip side of fat-burning is fat-storage. As you begin to lose weight the process of fat storage is up-regulated through an increase in an enzyme called Catechol-O-methyltransferase (COMT)! Epi-gall0catechin-3-gallate (EGCG) an active component of Green Tea, is a key component of WipeOut™ that inhibits COMT to counter any up-regulation of fat storage.¹² Reduced Lactate As lactate levels rise during intense exercise, fat burning falls off rapidly.13 Extracts containing EGCG have been shown to reduce lactate levels in exercising mice to non-exercise levels. Green Tea has further been shown to increase fat burning as a proportion of total calories burned.¹⁴ Improved Nitric Oxide With all the talk about nitric oxide and muscle-pump, it may surprise you to find out that nitric oxide is essential for fat release.¹⁵ And as any athlete knows, nitric oxide down-regulates with dieting (when you diet its harder to get a pump). L-Carnitine has recently been shown to improve resting nitrate and nitrite levels.16 Here again, WipeOut™ protects your body against the down-regulating effects of dieting so you lose weight more consistently. The Four Stages of Fat Loss 1. Exercise is the best way to burn fat. Unfortunately, exercise is also the fastest way to down-regulate the sympathetic nervous impulses that initiate triglyceride (Fat) release in fat tissue.¹ Trimethyl-Xanthine (Caffeine) in WipeOut™ stimulates sympathetic nerves to restore the process of Triglyceride release² (this fixes the short-term problem), while the ingredient Salycin from White Willow Bark prevents the long-term down-regulation of lipolysis (fat release) caused by inflammation and fatigue.³ 2. Once fat release has been stimulated, Triglycerides must be converted to Free-Fatty Acids (FFA) before they can be burned for energy. How well this happens determines how much FAA you will be able to burn during your workout. This process is carried out by an important fat cell busting enzyme, hormone-sensitive lipase (HSL). In order to do its job, HSL must move into Triglyceride droplets within fat cells.4 Here's where Theobromine, an extract of chocolate, counteracts the forces that would down-regulate this process and helps maintain a high-degree of FFA release.⁵ 3. Once Triglycerides have been converted to FFA it travels through your blood stream to your muscle cells. But before FFA can be burned it must be transported into 'the cell's furnace' (the mitochondria) within muscle cells. The body uses L-Carnitine to carry out this transport process. But here again, down-regulation threatens your success-dieting can down-regulate your body's production of L-Carnitine.⁶ L-Lysine in WipeOut™ provides your liver with the substrate for effective Carnitine formation and the addition of pure L-Carnitine to WipeOut™ further insures against any Carnitine shortage. 4. The last step in fat loss is 'the cell furnace' within muscle cells where fatty acids are burned-up. This is also your body's last chance to down-regulate fat burning. Dieting down-regulates the metabolic process called Krebs Cycle where the breakdown products of FFA are burned to regenerate ATP for energy release. This in turn, inhibits the effectiveness of L-Carnitine in order to prevent a backup of FFA in the cell.⁷ WipeOut™ contains Fumarate, a part of Krebs Cycle, which serves two purposes: First, it provides a critical substrate to prevent the down-regulation of Krebs Cycle.⁸ Second, it prevents the rise of Malonyl-CoA, the enzyme that prevents L-Carnitine from doing its job.⁹ The result is an efficient, effective metabolism (your metabolism) that is protected against down-regulation from the beginning to the end of your body's fat burning processes! The Last Word There has never been another product like WipeOut™ Fat Burner. Based on the most current scientific research, WipeOut™ is the first product designed to combat metabolic down-regulation - the unseen enemy of fat loss. Start seeing the rock-hard results you work so hard for. Add WipeOut™ to your diet and training regimen today, to help wipe out fat and get in the leanest, hardest shape of your life! 1. "A single bout of exercise induces beta-adrenergic desensitization in human adipose tissue". Fabrice Marion-Latard, Am J Physiol Regulatory Integrative Comp Physiol 280: R166-R173, 2001 2. "Sympathetic and sensory innervations of white adipose tissue" Bartness TJ, J. Lipid Res. 2007 48:1655-1672. 3. "Regulation of Leptin release and lipolysis by PGE2…" Fain J N, Prostaglandins Other Lipid Mediat. 2000 Oct;62;(4):343-50. 4. "Mechanism of hormone-stimulated lipolysis..." Egan JJ, Proc Natl Acad Sci U S A, 1992 Sep 15;89(18)8537-41 5. "Relationships between lipolysis induced by various lipolytic agents and hormone-sensitive lipase…" Morimoto C:J Lipid Res. 2001 Jan;42(1):120-7. 6. "Carnitine deficiency and supplementation…" Alan T. J. Nut. 135: 761-764 2005. 7. "Pathways and control of ketone body metabolism…" Fukao, Prostaglandins Leukotrienes and Essential Fatty acids 70 (3) : 243-251 March 2004. 8. "Ph regulation of endogenous acid production in subjects with chronic ketoacidosis" Hood VL, Am J of Physiol 249 (2 Part 2) : F220-F226 1985 9. "Inhibition of pyruvate carboxylation…" Mehlman M, 1968 J Biol Biochem 243 (8) : 1919-1925. 10. Ergosteroids II: Biologically active metabolites…" Lardy H, Steroids 1998 Mar;63(3):158-65 11. "The effect of the ergosteroid 7-oxo-dehydroepiandrosterone…" Bobyleva V, Arch Biochem Biophys. 1997 May 1;341(1):122-8 12. "Inhibitory effect of (-)-epigallocatechin-3-gallate on lipid accumulation…" Moon HS, Obesity (Silver Spring) 2007 Nov;15(11):2571-82 13. "Effect of Lactate on FFA release…" Gorski J Acta PHysiol Pol. 1977 Nov-Dec;28;(6):505-10. 14. "Green tea extract improves running endurance in mice by stimulating lipid utilization" Murase T, Am J Physiol Regul Integr Comp Physiol. 2006 Jun;290(6):R1550-6. 15. "A combination of Caffeine, Arginine, soy isoflavone, and L-Carnitine enhances lipolysis and fatty acid oxidation…" Murosaki S, J Nutr. 2007 Oct;137(10):2252-7 16. "Carnitine deficiency and supplementation…" Alan T. J. Nut. 135: 761-764 2005.